Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis

Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br/>SignificanceOur study reveals a mechanism by which heme and ecDNA contribute to lupus with hemolytic anemia (HA). Although ecDNA has been previously implicated in lupus pathogenesis, no studies have addressed the additive or synergistic effects of heme …