Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism

Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br/>SignificanceHealthy bone depends on the proper function of osteoclasts, the cells that break down bone during normal remodeling. Using mouse models, we uncover an unexpected role for the immune surveillance protein collectin-11 in supporting osteoclast …