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Reversibility and β-sheet formation are decoupled in tau condensate aging

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Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceAn aberrant phase transition of tau protein into insoluble protein aggregates is implicated in Alzheimer’s disease. Growing evidence suggests that early tau aggregation can be mediated by biomolecular condensates. However, the process by which …

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