ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study

Proceedings of the National Academy of Sciences, Volume 123, Number 11, March 2026.
Significance This study identified the polyamine pathway as being associated with meningeal inflammation in multiple sclerosis, a clinical phenotype associated with worse disease outcomes and lack of targeted therapies. Using experimental mouse models, we…