The cross-linking activity of transglutaminase 2 drives α-Synuclein pathology in synucleinopathy models
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Proceedings of the National Academy of Sciences, Volume 123, Number 12, March 2026.
SignificanceTransglutaminase 2 (TG2) has been implicated in common neurodegenerative diseases and particularly in synucleinopathies which include Parkinson’s disease (PD) and dementia with Lewy bodies. However, due to its multidomain and multifunctional nature…
