Mining cancer genomes for copy number alterations identifies glycosylation enzymes as oncogenic drivers

Proceedings of the National Academy of Sciences, Volume 123, Issue 14, April 2026. <br/>SignificanceIn this study, we reveal that cancer can be driven by genomic amplification of glycogenes, expanding the repertoire of druggable oncogenes. Using our pipeline, we identifiedB4GALT5, encoding a key enzyme of the glycosphingolipid (GSL) pathway,…