Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia

Proceedings of the National Academy of Sciences, Volume 122, Issue 28, July 2025. <br/>SignificanceCardiac sodium–calcium exchanger (NCX1), the dominant calcium (Ca) efflux mechanism in cardiomyocytes, is strongly regulated by pH. However, the physiological relevance of NCX1 pH regulation in diseases such as cardiac ischemia remains …