A scalable embryonic stem cell–based platform for efficient generation of mitochondrial DNA mutant mice

Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. <br/>SignificanceMitochondrial DNA (mtDNA) accumulates mutations at a high rate, and more than 260 pathogenic germline mtDNA mutations have been identified in humans, producing diverse and often tissue-specific disorders. In addition, numerous population-…