Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1

Proceedings of the National Academy of Sciences, Volume 123, Number 15, April 2026.
Significance Few reversible male contraceptives have progressed toward clinical application, largely because the optimal biological stage for safe intervention remains undefined. Meiosis represents a natural control point in sperm production where transient phenomena…