A universal polymer signature in Hi-C resolves cohesin loop density and supports monomeric extrusion

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. <br/>SignificanceLoop extrusion is believed to dynamically fold meter-long DNA inside a micrometer-sized nucleus, yet the density of these loops has remained unknown. A central obstacle is that Hi-C contact maps encode chromatin structure through a biochemical …