From Drosophila to mammals: The evolutionarily conserved homeodomain protein Engrailed affects the antitumor innate immune response

Proceedings of the National Academy of Sciences, Volume 123, Issue 17, April 2026. <br/>SignificanceIn the process of investigating the potential induction of host defense genes in adult flies following injection of oncogenic cells, we identified theengrailedgene initially discovered as a homeobox protein acting as a transcription factor …