The WWP1–JARID1B axis sustains acute myeloid leukemia chemoresistance

Proceedings of the National Academy of Sciences, Volume 122, number 28, July 2025.
Significantly characterized the molecular mechanism of chemoresistance in acute myeloid leukemia (AML), our study identified the histone Lysine Démethylase Jarid1b as a substrate of the Ubiquitin ligase Histrone Ligase wwp1. The cooperating oncogen …