Aurora-A drives sorafenib resistance by scaffolding stress granule assembly via phase separation

Proceedings of the National Academy of Sciences, Volume 123, Issue 17, April 2026. <br/>SignificanceThis study reveals how cancer cells resist the targeted drug sorafenib. We found that the protein Aurora-A, known for its role in cell division, can form liquid-like droplets in the cytoplasm under drug stress. These droplets help build …