Targeted knockout of a host peroxisomal peptidase confers field resistance to maize lethal necrosis

Proceedings of the National Academy of Sciences, Volume 123, Issue 18, May 2026. <br/>SignificanceMaize lethal necrosis (MLN) is a serious viral disease threatening food security in East Africa. We found a previously unknown mechanism by which the virus exploits a specific maize peroxisomal peptidase to form replication compartments. This …