HIV-1 infection induces Vif-mediated SUMOylation of host RNA splicing factors important for proper viral RNA splicing

Proceedings of the National Academy of Sciences, Volume 123, Number 18, May 2026.
ImportanceSUMOylation has not been explored by large-scale proteomics in the context of HIV-1 infection. We performed an unbiased mass spectrometry (MS)-based screen to identify host cellular proteins that are SUMOylated during HIV-1 infection. We show…