Common inherited loss-of-function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy

Proceedings of the National Academy of Sciences, Volume 122, number 28, July 2025.
Significant results help explain, in part, the great variability of the clinical response to immunotherapy against cancer widely used by revealing a contribution inherited from common functional variants in a single gene, nod2. The results show that nod2 …