Eosinophil-derived COX-2 protects against experimental colitis through the PGE2–IL-22 axis

Proceedings of the National Academy of Sciences, Volume 123, Issue 19, May 2026. <br/>SignificanceAlthough eosinophils are consistently associated with inflammatory bowel disease (IBD), their precise functional roles and mechanisms of action in disease remain incompletely defined. We identify eosinophil-derived COX-2 as the main source of …