AI-driven framework enables precise prediction of RNA splicing and isoform usage

RNA is the means of translating the genetic code embedded in DNA into proteins, which serve as enzymes, transporters, signaling molecules, receptors, structural components, regulators, and controllers of gene expression, among other roles. However, a gene is not limited to producing a single RNA variant. The process of RNA splicing – in which different coding RNA segments (exons) are joined together after removal of non-coding regions (introns) – allows the generation of a wide range of RNA transcript isoforms with distinct sequences and, therefore, distinct functions in tissue- and cell type-specific patterns.