Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes

Proceedings of the National Academy of Sciences, Volume 122, number 29, July 2025.
Significant on the Ionian channel TRPV1 plays several important physiological roles, in particular the detection of nociceptive and inflammatory stimuli. Several TRPV1 activators have been described, but very few natural antagonists have been found. For hundreds …