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Cell type–specific purifying selection of synonymous mitochondrial DNA variation

https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c

Proceedings of the National Academy of Sciences, Volume 122, Issue 30, July 2025. <br/>SignificanceWe identify the cell type–specific selection of T cells with a synonymous mitochondrial DNA variant inMT-CO1,reminiscent of the purifying selection of pathogenic alleles. Mechanistically, we implicate the limited mitochondrial tRNA pool to …

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