Therapeutic CD8+ T cell tissue retention and immunomodulation during ART interruption fail to prevent SIV rebound

Proceedings of the National Academy of Sciences, Volume 122, Issue 33, August 2025. <br/>SignificanceHIV therapeutic and cure strategies have all operated under the assumption that CD8+T cells can become cytotoxic in lymph nodes to eliminate infected cells from reservoir repositories. Using FTY720 to prevent lymphocyte egress from lymph …