Diverse thioether macrocyclized peptides through a radical SAM maturase

Proceedings of the National Academy of Sciences, Volume 122, number 34, August 2025.
Significant roads to cyclical peptides containing Thioéther are based on preinstalled electrophiles and often complex syntheses, restricting the diversity of scaffolding and limiting applications. We found that the radical enzyme-adenosyl-l-methionine, PAPB, …