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ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
Proceedings of the National Academy of Sciences, Volume 122, Issue 34, August 2025. <br/>SignificanceToll-like receptor 4 (TLR4), a key mammalian pattern recognition receptor, mediates proinflammatory signaling in response to pathogenic stimuli. Here, we identify CCDC134 as a critical regulator of TLR4 biogenesis. Unlike its secreted form, …


