A general genome editing strategy using CRISPR lipid nanoparticle spherical nucleic acids

Proceedings of the National Academy of Sciences, Volume 122, Issue 36, September 2025. <br/>SignificanceGenome editing holds broad therapeutic potential, but clinical translation requires efficient delivery of genome editors to target cells and tissues. We modified lipid nanoparticles (LNPs) with a dense shell of DNA to create CRISPR LNP–…