A distinct subclade of AlkB family demethylases in ciliates safeguards the positional fidelity of eukaryotic N6-methyladenine (6mA)

Proceedings of the National Academy of Sciences, Volume 123, Issue 10, March 2026. <br/>SignificanceN6-methyladenine (6mA) is a key epigenetic mark in unicellular eukaryotes. Although the pathways for its establishment and inheritance are well defined, the mechanism underlying its removal has remained unclear. Here, we identify an AlkB …