A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron–sulfur cluster and supercomplex formation
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Proceedings of the National Academy of Sciences, Volume 122, Number 40, October 2025.
ImportanceThe mitochondrial fatty acid synthesis pathway is necessary for mitochondrial ATP production, but its mechanism is unknown. Individuals carrying mutations in MECR, encoding the final step of mtFASII, exhibit early neurological dysfunction. We …
