A TGF-βR/IL-2R immunomodulatory fusion protein transforms immunosuppression into T cell activation to enhance adoptive T cell therapy

Proceedings of the National Academy of Sciences, Volume 122, Issue 39, September 2025. <br/>SignificanceAdoptive T cell therapy has shown limited success in solid tumors due in part to immunosuppressive factors such as Transforming growth factor (TGF)-β and to limited proliferative signals within the tumor microenvironment. We developed a class …