Functional spectrum of USP7 pathogenic variants in Hao–Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation

Proceedings of the National Academy of Sciences, Volume 122, Issue 39, September 2025. <br/>SignificanceMutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7) are implicated in Hao–Fountain syndrome, a neurodevelopmental disorder currently lacking targeted therapies. Despite USP7’s established links to cancer and …