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Absolute hand determination of glycofibrils from natural sources in cryo-EM

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Proceedings of the National Academy of Sciences, Volume 123, Issue 9, March 2026. <br/>SignificanceGlycans represent not only one of the four fundamental macromolecular classes essential to life, but also the most abundant among these four across the Earth. However, their structural and stereochemical characterization lags far behind that …

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