Accurate conformational ensembles of intrinsically disordered proteins using reweighting based on NMR chemical shifts

Proceedings of the National Academy of Sciences, Volume 123, Number 8, February 2026.
ImportanceMany proteins contain regions that never settle into a well-defined structure: they continually switch between several conformations. These heterogeneous regions are crucial for health and disease, but remain difficult to characterize. We are merging…