Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis

Proceedings of the National Academy of Sciences, Volume 122, Number 49, December 2025.
SignificanceThe emergence of hematopoietic stem and progenitor cells (HSPCs) during embryogenesis is a finely tuned process that relies on a delicate balance of inflammatory signals. While previous studies have identified pro-inflammatory pathways critical to HSPC…