Metabolite control of enzyme activity links stress to biosynthetic regulation

Proceedings of the National Academy of Sciences, Volume 123, Number 6, February 2026.
SignificanceMetabolite-mediated feedback represents a rather unexplored mode of metabolic regulation in plants and other organisms. This study identifies methylerythritol cyclodiphosphate (MEcPP), an intermediate of methylerythritol phosphate (MEP)…