Allosteric coupling between PIP2 and Ca2+ binding sites gates TMEM16A channels

Proceedings of the National Academy of Sciences, Volume 123, Number 7, February 2026.
SignificanceTMEM16A is a Ca2+-activated chloride channel expressed in various tissues, where it regulates electrical excitability, cell volume, ionic homeostasis, and solute transport. TMEM16A dysfunction is linked to conditions such as hypertension,…