Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates

Proceedings of the National Academy of Sciences, Volume 122, Issue 32, August 2025. <br/>SignificanceDuring development, cells generate shape through self-organization and prepatterning. How mechanics impact collective cell organization remains unknown. We used Hydra’s ability to regenerate itself: Aggregates of dissociated cells initially …