Houston vs. Iowa State prediction, odds, spread, line, time: 2026 college basketball picks from proven model

In Monday’s top 5 college basketball schedule, the Houston Cougars will visit the Iowa State Cyclones. The No. 3 Cougars (23-2, 11-1 Big 12) are riding a six-game winning streak, sit atop the Big 12 standings and beat Kansas State, 78-64, on Saturday. No. 5 Iowa State (22-3, 9-3) has won six of its last seven games and is coming off a double-digit victory Saturday against No. 9 Kansas. These programs have split four meetings all-time.

Tip-off will take place at 9 p.m. ET from the Hilton Coliseum in Ames, Iowa. The Cyclones are 2.5-point favorites in the latest Iowa State vs. Houston odds from DraftKings Sportsbook, while the over/under in total points scored is 134.5. Before making any Houston vs. Iowa State picks, check out men’s college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and enters Week 15 on a torrid 11-1 streak on its top-rated over/under college basketball picks dating back to last season, and is on an 11-5 streak on the CBB’s top-rated side picks. Anyone who followed his college basketball betting tips on sportsbooks and betting apps could have seen solid returns.

Today, the model has simulated Iowa State vs. Houston 10,000 times and just revealed its coveted men’s college basketball picks and betting predictions. You can now head over to SportsLine to see the model’s choices. Here are several men’s college basketball odds and men’s college basketball betting lines for Houston vs. Iowa State:

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How to make choices between Houston and Iowa State

SportsLine’s model has simulated Iowa State vs. Houston 10,000 times and is exceeding the total (135.5 points). Houston takes its offense to another level against a ranked opponent as the Over is 4-2 in Cougars games against ranked teams. The Coogs’ offense, overall, is among the most efficient in the country, as no team commits fewer turnovers, which leads to more scoring opportunities.

As for ISU, there are few better shooting teams in all of college basketball. The Cyclones rank seventh in 3-point percentage and 13th in field goal percentage, giving them the 12th offensive rating in the country. With the power of two competent offenses, each team should allow seven or more points than they give up on average. So the Over hits with plenty of points to spare with simulations calling for a combined 146 points. The total is eclipsed in 80% of cases.

The model also indicates that one side of the gap hits more than 50% of the time. You can only see this pick on SportsLine.

So who wins against Iowa State in Houston, and which side of the spread reaches more than 50% of the time? Visit SportsLine now to see which way Iowa State vs. Houston went, all from the advanced model that has simulated this game 10,000 times, and find out.