Prevention of ubiquitination at K6 and K9 in mutant huntingtin exacerbates disease pathology in a knock-in mouse model

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. <br/>SignificanceUbiquitination is a hallmark of mutant huntingtin (mHTT) aggregates, potentially preceding or promoting their degradation or accumulation. However, how specific ubiquitination events shape the fate of mHTT in vivo remains unclear. Here, using …