ATP13A2 restrains macrophage NLRP3 inflammasome activation to repress neurodegeneration via modulating mitochondrial homeostasis

Proceedings of the National Academy of Sciences, volume 123, number 12, March 2026.
SignificanceATP13A2 is a key genetic factor in KRS, a juvenile form of Parkinson’s disease (PD). While its neuroprotective mechanisms are increasingly better understood, the impact of pathogenic ATP13A2 mutations on the immune system to contribute to the progression of PD…