Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases

Proceedings of the National Academy of Sciences, Volume 122, Issue 33, August 2025. <br/>SignificanceThe dynamics of meningeal adaptive immunity, a crucial gateway to the brain, remain unclear. Here, we provide a comprehensive mapping of dural ectopic lymphoid structures (ELS), which exhibit age-, sex-, and brain pathology–specific patterns. …