TCR signal–enhancing mutation alters lipid metabolism of thymocytes and impairs antitumor immunity of mature T cells

Proceedings of the National Academy of Sciences, Volume 122, Issue 42, October 2025. <br/>SignificanceOur study reveals that T cell development is tightly controlled by an evolutionarily optimized T cell receptor (TCR) signal strength, where both excessive and insufficient signals compromise mature T cell function and antitumor immunity. …