METTL3-mediated N6-methyladenosine modification of Dnajb1 modulates cardiomyocyte ferroptosis during myocardial infarction

Proceedings of the National Academy of Sciences, Volume 123, Number 10, March 2026.
SignificanceThe differential m6A modification of the Dnajb1 gene has been shown to play an essential role in the regulation of ferroptosis during the pathological process of MI. High expression of METTL3 increased the m6A modification of Dnajb1, destabilizing it by competing…