Nonsubstrate PI(4,5)P2 interacts with the interdomain linker to control electrochemical coupling in voltage-sensing phosphatase (VSP)

Proceedings of the National Academy of Sciences, Volume 122, Issue 31, August 2025. <br/>SignificancePI(4,5)P2is a fundamental modulator of voltage-gated ion channels (VGICs). The PI(4,5)P2phosphatase, voltage-sensing phosphatase (VSP), in which a cytoplasmic catalytic region (CCR) is connected with a voltage sensor domain (VSD) similar to …