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BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance

https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c

Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceExtrachromosomal circular DNA (ecDNA) is a powerful driver of cancer evolution, enabling tumor cells to rapidly amplify oncogenes and develop drug resistance. Yet, how ecDNA forms inside cells has remained a long-standing mystery. Here, we …

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