C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer’s disease and mediates synapse pruning

Proceedings of the National Academy of Sciences, Volume 122, Issue 38, September 2025. <br/>SignificanceA complex interplay of mechanisms and cell types regulates synapse stabilization and pruning throughout life. The complement cascade contributes by activating glia, leading to pruning. Neurons also express receptors implicated in pruning, …