Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse

Proceedings of the National Academy of Sciences, Volume 122, Issue 32, August 2025. <br/>SignificanceOur findings provide insights into previously uncharacterized dynamics at the cancer cell–cytotoxic lymphocyte interface, uncovering a critical mechanism by which actin cytoskeleton remodeling at the cancer cell side promotes resistance to …