Assembling more than 1,000 human genomes affordably: New method could power genetic screening's future

A research team led by Zhen-Xing Endowed Professor Jian Yang in the School of Life Sciences at Westlake University has developed a pangenome-informed genome assembly (PIGA) method. By combining a cost-effective hybrid sequencing strategy of long and short reads, the team successfully constructed a pangenome for more than 1,000 individuals. This achievement goes beyond the limitations of previous small-sample pangenomes and provides essential fundamental infrastructure for medical and population genetics research. The study is published in the journal Nature.