CDKL5 modulates the plasticity of excitatory synapses via liquid–liquid phase separation

Proceedings of the National Academy of Sciences, Volume 123, Number 8, February 2026.
Significance Mutations in the cyclin-dependent kinase-like 5 (CDKL5) gene cause CDKL5 deficiency disorder, a devastating neurodevelopmental disease characterized by early-onset epilepsy, severe intellectual disability, and autistic features. Despite its…