Charge-reversal proteolysis polymers enable tissue-specific STING degradation in rheumatoid arthritis

Proceedings of the National Academy of Sciences, Volume 123, Issue 11, March 2026. <br/>SignificanceRheumatoid arthritis (RA) is a debilitating disease characterized by autoimmune attack on the joints. The stimulator of interferon genes (STING) is a critical mediator of this pathogenesis. However, its systemic inhibition carries significant …