An accurate cellular assay to determine pathogenicity of coding and noncoding variants in Lynch syndrome genes

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. <br/>SignificanceThe gastrointestinal and genitourinary cancer predisposition Lynch syndrome is caused by overt deleterious germline mutations in DNA mismatch repair (MMR) genes. However, germline sequencing often reveals subtle base-pair substitutions in MMR …