Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis

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Proceedings of the National Academy of Sciences, Volume 123, Number 2, January 2026.
SignificanceTissue stiffening may contribute to liver fibrosis, but how lipid accumulation affects tissue stiffness in metabolic dysfunction-associated steatotic liver disease (MASLD) is unclear. We find that lipid crystals induced by dietary cholesterol…

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