Cryo-EM structure of locked spike glycoprotein from bat SARS-like coronavirus WIV1, molecular dynamics and biophysics across host range

Proceedings of the National Academy of Sciences, Volume 123, Issue 8, February 2026. <br/>SignificanceUnderstanding how SARS-like coronaviruses (SL-CoVs) spill over into human population is critical for anticipating and preventing future pandemics. WIV1 is a concerning SL-CoV, given its capability to infect multiple mammals. The herein …